Stefanie Dolson and Bria Hartley each have 10 points and seven rebounds to lead the Huskies, who shot 39 percent from the field (4-of-18 3-pointers) and committed 12 turnovers.
UConn used a 10-2 run to open a 26-14 lead with 7:30 left in the half. The lead grew to as big as 16 (37-21) in the half.
Jude Schimmel had six points to lead Louisville. The Cardinals shot 31 percent from the field (2-of-10 3-pointers) and committed 13 turnovers.