Stefanie Dolson had 15 points and six rebounds and Kaleena Mosqueda-Lewis added 14 points and four assists for UConn.
The Huskies opened the game by scoring the first seven points. They added runs of 10-0 and 15-0 in the half.
UConn’s lead is 27 at the half despite going scoreless for the final 4:32.
Taylor Holeman, Laura Sweeney and Rachel Roberts each have four points for Villanova. The Wildcats missed their first nine 3-pointers and are shooting 29.6 percent from the field.