Stefanie Dolson has 22 points (9-of-9 FT), four rebounds and four assists to lead the Huskies. Bria Hartley has 10 points, four rebounds and three assists.
UConn made its first five shots of the game and six of eight to open a 15-3 lead.
Megan Podkowa has eight points for DePaul. The Blue Demons, who missed 15 of their first 17 shots, are shooting 30.3 percent from the field (4-of-16 3-pointers).