Kaleena Mosqueda-Lewis has 13 points (3-of-4 3-pointers) to lead the Huskies. Stefanie Dolson has eight points and five rebounds.
UConn coach Geno Auriemma was hit with a technical foul with 8:21 left after a bad call on Dolson for her second foul.
The Huskies, who have nine turnovers, overcame a scoreless stretch of 5:02 and finished the half with an 8-4 run.
Skylar Diggins and Kayla McBride each have 11 points for Notre Dame. The Irish are shooting 30.0 percent from the field.