Stefanie Dolson has 12 points and seven rebounds to lead the Huskies. Breanna Stewart has 10 points and three rebounds.
UConn opened the game by missing nine of its first 11 shots. However, it finished the half by making 17 of its last 26.
With the game tied 7-7, the Huskies scored 13 straight points as part of a 34-3 run. They would score 21 straight points to cap the run.
Boston University is 5-of-21 from the field and has committed 17 turnovers.