Peter Gabriel: The 62-year-old singer is currently on the tour Back To Front Tour celebrating the 25th anniversary of his breakthrough album, "So." He says, "I had a conversation with John Cusack saying we're forever trapped in a bubble of contemporary culture together because of that scene with the boom box in 'Say Anything.'"
Madonna: At 54, she can still turn heads. More than with 114 million viewers tuned into the Super Bowl halftime show to watch her cheerleading moves while her MDNA Tour is drawing headlines daily.
Hall and Oates: Not the same without the mustache, the blue-eyed-soul duo has nonetheless become an improbable pop culture staple thanks to hipster DJs rediscovering the silky grooves of "I Can't Go for That (No Can Do)" and "One on One."
George Michael: Following a spell of terrible driving habits and near fatal bout of pneumonia, the 49-year-old former Wham! star recently resumed his Symphonica Tour, performing orchestral versions of his biggest hits.
Duran Duran: The five original members of the British pop group reunited earlier in the decade (that didn't last) and in 2010 released an album produced by Mark Ronson (Adele, Amy Winehouse). Despite intermittent health problems, they have been on tour ever since.
Boy George: After a few bizarre run-ins with the law, the 51-year-old Culture Club singer's only addiction these days appears to be Twitter. "My head is firmly screwed back on - the right way - and I am a far saner human being than I have been in a long time, if not forever," he says.
Prince: He hasn't released anything interesting in a while but the 54-year-old's concerts are still unrivaled, even with the new intergalactic getup. "I've got too many hits," he says.
Paul Young: The '80s pinup had a hit with "Everytime You Go Away" and big role in the Band Aid singalong. Since then, the 54-year-old Young has toured his back catalog and occasionally plays with Tex-Mex group Los Pacaminos.
Axl Rose: Not quite the svelte figure of the "Welcome To The Jungle" days, the 50-year-old Guns N' Roses frontman has been touring with a makeshift version of the hard rock group and steadily avoiding making a new album.
Adam Ant: The 57-year-old pop buccaneer's career was derailed by mental illness but in the past year he has been well enough to tour the world and make plans to release his sixth studio album, "Adam Ant is the Blueblack Hussar in Marrying the Gunner's Daughter."
A Flock of Seagulls: Swoop-haired frontman Mike Score long ago ditched the flock, which included his brother Ali, but thanks to hits like "I Ran" and "Space Age Love Song" remains a regular on the county fair and casino circuit.
Morrissey: The 53-year-old British pop icon has alternately threatened to retire and reunite the Smiths. Neither seems likely as he presses forth with another one of his sporadic solo tours.
Depeche Mode: The synth-pop group's frontman Dave Gahan suffered a near-fatal overdose in a Los Angeles hotel room in 1996 but the members of Depeche Mode eventually got clean and reconvened, releasing its most recent album, "Sounds of the Universe," in 2009.
Chuck D: It's been a wild career for the 52-year-old Public Enemy frontman, from fighting the power back in the day to trading verses with Meat Loaf last year. His band plays the Treasure Island Music Festival in October.
Siouxsie Sioux: The 55-year-old lead singer of Siouxsie and the Banshees' influence can be heard in artists as diverse as PJ Harvey, Santigold and Karen O.
Bruce Springsteen: The Boss, 63, has been playing marathon sets with the E Street Band on this year's Wrecking Ball Tour. The album that inspired the tour became Springsteen's tenth No. 1 charting release.
The Go-Go's: Last year, the original members got back together for the Ladies Gone Wild Tour to commemorate the 30th anniversary of the release of "Beauty and the Beat," which included "Our Lips Are Sealed" and "We Got The Beat."
Jon Bon Jovi: In addition to his acting career and social work, Bon Jovi is a regular arena draw. Last year its Circle Tour earned over $190-million. The band is currently writing songs for its next album.
Kajagoogoo: The band broke up shortly after "Too Shy" became a global hit but recent years have seen the members put differences aside to hit the retro festival circuit in Europe.
Robert Smith of the Cure: The band, famous for hits "Just Like Heaven" and "Boys Don't Cry," spent the summer headlining the Reading and Leeds Festivals in the U.K.
Journey: Steve Perry's departure was but a minor setback for the Bay Area pop band, which went through several replacements before settling on Filipino singer Arnel Pineda after band co-founder Neal Schon found him singing Journey songs on YouTube.
David Byrne: The 60-year-old Talking Heads singer has a regular cycling column in the New York Times and last month released an album with with St. Vincent, "Love This Giant." They are touring together now.
U2: The group's 360° Tour drew a record-setting 7,268,430 attendance record. Its currently working on a new album.
Huey Lewis: He scored a string of hits with Huey Lewis and the News, including "I Want a New Drug" and "Power of Love." The group's most recent album was 2010's Stax Records tribute, "Soulsville." Lewis also starred with Gwyneth Paltrow in the 2000 movie "Duets."
Devo: The "Whip It" hit-makers have toured regularly, and recently released a single called "Don’t Roof Rack Me, Bro (Seamus Unleashed)," dedicated to Republican presidential candidate Mitt Romney's former pet dog Seamus.
Richard Butler of the Psychedelic Furs: Famous for '80s pop staples "Pretty In Pink" and "Love My Way," the group has been on several package tours with bands from the era.
The Bangles: Massive hits like "Walk Like An Egyptian" and "Manic Monday" drove the band apart but they put the members eventually put personal differences aside. They released the album "Sweetheart of the Sun" last year.
Sting: The 61-year-old Police frontman recently collaborated with Nicole Scherzinger and Vince Gill, while playing string version of his hits on the Symphonicity Tour.
Red Hot Chili Peppers: Still a major arena draw, the Los Angeles band kicked off the I'm with You Tour in Sept. 2011 and will continue playing around the world well into 2013.
Michael Stipe: The 52-year-old singer has kept a low profile since R.E.M. finally called it quits last year but "Stand" remains an inescapable pop blight.
Pet Shop Boys: The synth-pop duo performed "West End Girls" in the closing ceremony of the 2012 Olympic Games and is preparing to release its eleventh studio album, "Elysium."
Lionel Richie: On his latest album, "Tuskegee," Richie reinterprets his biggest hits as duets with country stars such as Sugarland’s Jennifer Nettles, Tim McGraw and Willie Nelson.
Annie Lennox: The Eurythmics singer, famous for hits like "Sweet Dreams (Are Made of This)" and "Here Comes The Rain Again," has dedicated her time to charity work. Her most recent release was 2010's "A Christmas Cornucopia."
Metallica: The San Francisco heavy metal band's Lou Reed collaboration, "Lulu," took a critical beating but that didn't put a damper on its 30th anniversary celebrations, which included starting a new music festival called Orion Music + More and headlining Outside Lands.
LL Cool J: The 44-year-old rapper has a second career as NCIS Special Agent Sam Hanna on the CBS crime drama television series "NCIS: Los Angeles."
Mötley Crüe: Despite in-fighting, substance abuse and various arrests, the heavy metal band is still going strong. "All the turmoil made us a better band," says singer Vince Neil.
Nick Cave: From the Birthday Party to Grinderman, the 55-year-old Australian musician has kept music reliably evil. "I saw a therapist for about maybe six months," he says. "He was not interested in any problems I had whatsoever."
Def Leppard: The British hard rock group, whose '80s albums "Pyromania" and "Hysteria" were both certified Diamond, has been on several package tours of late with contemporaries such as Heart, Poison and Lita Ford.
Bob Mould: The 51-year-old Mould has remained uncompromising, from his days as the frontman for Minneapolis indie rock heroes Hüsker Dü to his current career as a gay dance club DJ and successful solo career.
Run–D.M.C.: Jam-Master Jay was shot and killed at his recording studio in Queens in 2002, effectively ending the group's run. Joseph "Run" Simmons is now a practicing minister, reality TV star and Twitter celebrity.
EMI/Blinded by Science
Thomas Dolby: Best known for his 1982 hit "She Blinded Me with Science," Dolby still releases new music and is the musical director of the TED Conference.
Van Halen: After a successful run of reunion shows with David Lee Roth (with Eddie Van Halen's son Wolfgang replacing bassist Michael Anthony), the group abruptly postponed its tour earlier this year, citing a much-needed break.
Janet Jackson: The 46-year-old pop star, actress and Super Bowl troublemaker spent most of the last year embroiled in the surreal custody battle with her family over late brother Michael's children.
Paul Weller: The frontman for the Jam and Style Council, Weller received the coveted Godlike Genius Award from the NME. He released his eleventh solo album, "Sonik Kicks," earlier this year.